Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer

D Wu, D Hu, H Chen, G Shi, IS Fetahu, F Wu… - Nature, 2018 - nature.com
Diabetes is a complex metabolic syndrome that is characterized by prolonged high blood
glucose levels and frequently associated with life-threatening complications,.
Epidemiological studies have suggested that diabetes is also linked to an increased risk of
cancer–. High glucose levels may be a prevailing factor that contributes to the link between
diabetes and cancer, but little is known about the molecular basis of this link and how the
high glucose state may drive genetic and/or epigenetic alterations that result in a cancer …
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